Clinical use of Tetracycline
Tetracycline is primarily used for the treatment of Acne Vulgaris and Rosacea. Tetracycline hydrochloride is indicated for the treatment of Rocky Mountain spotted Fever, Q- fever, Typhus fever, Respiratory tract infections, Chlamydia tracomatis (Uncomplicated urethral and endocervical or rectal infections, conjunctivitis etc.).
Tetracycline is also used for the treatment of Chancroid, Plague, Cholera, Tularemia, Syphilis, Anthrax, Actinomycosis, Acute Intestinal Amebiasis, Listeriosis, Vincent’s infection and many other bacterial infections.
Available Preparation
Tetracycline is availale in 250mg, 500mg oral tablets format.
Storage Instruction
Store in a tightly closed container at room temperature (15°c-30°c) and at a dry place. Keep away from the children.
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What is the preferred dosage for Tetracycline?
- For moderate to moderately severe infections in adults - 500mg twice daily or 250mg thrice daily may be applied. 500mg trice daily may be required in case of severe infections.
- For moderate to moderately severe infections in children above 8 years of age – (25mg-50mg) per Kg body weight divided in four equal doses.
- For treatment of uncomplicated gonorrhea – 500mg 4times daily (every 6 hour) for 7 days.
- For uncomplicated urethral and endocervical or rectal infections in adult – 500mg 4times daily for 7 days.
- For treatment of syphilis – 4000mg of tetracycline in equally divided doses for a period of 10-12 days.
- For severe acne – 250mg 4times daily for first seven days and thereafter 125mg to 500mg daily until the remission of the lesions.
Usual dose for adult in moderate infections is 1gm-2gm/day 2 or 4 equally divided doses and for children above 8 years 25mg to 50mg/Kg body weight/day 2 or 4 equally divided doses. For severe infections doses may be increased. Tetracycline should not be administered in children below 8 years. Doses should be taken 2 hour before or after meal as food reduces the absorption of the drug.
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What are the side effects of Tetracycline?
Less serious commonly known side effects of tetracycline drug include:
- Mild nausea, Vomiting, Stomach upset.
- Sores and swelling in rectal or genital organ.
- Sores inside mouth or on leaps and tongue.
- Vaginal itching or discharge
- Tetracycline can make skin over sensitive to sunlight and UV rays.
Some serious side effects may occur in few individuals those are hypersensitive (allergic) to tetracycline.
- Severe pain in upper stomach spreading to the back, nausea and vomiting, fast heart rate.
- Less urine passes or stops passing urine.
- Sever formation of blister.
- Loss of appetite, jaundice.
- Bleeding, unusual weakness, rash.
- Dizziness, severe headache, blurred vision.
- Arthralgia, urticaria, pericarditis, angioneurotic edema.
Prolong use of tetracycline may cause black-brown microscopic discoloration of thyroid gland but no abnormalities of thyroid function are observed. Tetracycline should not be given to the children below 8 years because it may affect the growth of the children and can cause permanent discoloration of teeth in later life.
Emergency medical help should be taken if hypersensitive reaction takes place while using tetracycline.
Drug interactions
- Since penicillin and tetracycline both is bacteriostatic drug, so penicillin should not be combined with tetracycline.
- Aluminum, magnesium, calcium and iron containing antacids can impair the action of tetracycline.
- Tetracycline and methoxyflurane should not be used simultaneously, because it may cause fatal renal toxicity.
- Cholesterol-lowering and anticoagulant medication should not be used concurrently with tetracycline.
- Tetracycline may cause birth control pill less effective.
This is not a complete list of drugs those can interact with tetracycline. Consultation with a medical practitioner is required about the other prescribed drug and over the counter drug before using tetracycline.
Effects of Tetracycline during Pregnancy
Tetracycline should not be taken during the period of pregnancy. It may reach harm to the unborn baby and affect the growth of the fetus.
Tetracycline passes into the breast milk and hence a breast-feeding mother should not use the medication.
How to use Tetracycline?
- Tetracycline should be taken 2 hours before or after meal.
- In case of stomach upset Tetracycline should be taken with food
- Milk and dairy product reduce the activity of tetracycline.
- Tetracycline should be taken always with a full glass of water
- Always try to maintain equal time interval while taking the doses
- Complete the course of the medication as directed by a medical practitioner.
Missed dose
A missed dose should be taken as soon as it is remembered. If it is time for the next dose, skip the dose. Overdose of Tetracycline may lead to severe adverse effect. In case of overdose seek emergency medical help.
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