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| Xenical (Generic Name Orlistat) |
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What is Xenical?
Xenical is the trade name of orlistat, a medication, very commonly used for the treatment of obesity. Another name is Tetrahydrolipstatin. The IUPAC name (systematic chemical name) is [(1S)-1-[(2S, 3S)-3-hexyl-4-oxo-oxetan-2-yl] methyl] dodecyl] (2S)-2-formamido-4-methyl-pentanoate.
The action of Xenical in promotion of weight loss is already verified and tested. The effect of Xenical is definite but modest on the obese person in reducing weight. It is also determined that Xenical can prevent the onset of type 2 diabetes in more or less 40% of the obese people.
Clinical Data
It is observed that the group of obese people given Xenical in addition to diet control and exercise, reduced 2.5 Kg to 3.5 Kg more weight than the other group of obese people of the same age group, those only controlled their diet and performed exercise.
Obesity is now one of the most important health problems in the 21st century especially in the developed western countries including the United States.
Obesity and risk factor
- Mechanical: - Due to the heavy weight of the body, the weight bearing joints like knee, hip, and lumber spine may develop osteoarthritic changes. Besides, abdominal hernia, varicose veins etc may be developed
- Cardiovascular: - Heart diseases such as angina pectoris, cardiac failure, myocardial infarction, hypertension may occur.
- Metabolic: - Diabetes, Choleslesterol stones, hyperlipidemia, gout etc may develop.
- Psychic: -Different psychosomatic problem may develop. From the aesthetic point of view obese individual very often feel unhappy.
- Cancer: -Some particular types of cancer particularly of gall bladder, colon and breast may be seen.
Who can take Xenical?
Body Mass Index or BMI is the simple and commonly used measure for body fat mass. It is the weight of the body in proportion to the height. The BMI in between 18.5/m2 to 24.5/m2 is considered as the normal weight. The BMI in between 25 to 30 is pre-obese and the BMI more than 30 is obese. Any BMI > 40 to 40.9 is severe and morbid obesity, while BMI > 50 is super obesity. So if body weight of any one progressively increases and gradually the contour and configuration of the body alter should take Xenical. Besides, symptoms like, slow movements due to body weight, dysponea or breathing problem due to slight exertion for the overweight, difficulty in sitting in squatting position, or difficulty in getting up or sitting on a chair or in a vehicle etc suggest to take Xenical. Patients with diabetes and high blood pressure with BMI more than 30, or patients with type 2 diabetes with BMI greater than 30 or persons with high cholesterol with BMI more than 30 may use Xenical.
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How Does Xenical works
Xenical is the simpler and stable saturated derivative of lipstatin which is a natural and strong inhibitor of pancreatic lipases (enzymes those decompose complex fats into simpler substances for digestion) and hence developed as an anti obesity drug. Xenical unites with the lipases and prevents them decomposing at least one third of fat of our food intake. Consequently undigested fat can’t be absorbed and is excreted out from our body along with stool. Some other anti obesity drugs are there those act on central nervous system to suppress the sense of appetite or speed up metabolism; but they are having greater side effects and withdrawal symptoms as well.
Dosage For Medicine Xenical
Standard prescription dose is 120 mg Xenical, three times daily before meal and it can prevent 30% of the fat absorption from our diet. No prior prescription is needed for over the counter dose. It is Xenical 60mg three times daily before the meal and it can prevent 25% of dietary fat from being absorbed.
Side effects for Xenical Tablets
The common side effects are: -
- Steatorrhea (oily, loose stool), due to the unabsorbed fat is excreted unchanged in the faeces.
- Frequent and urgent bowel movement
- Flatulence
Best part of the Xenical user experience G I related adverse effect in the 1st year and some of the user experience it in 4th year.
N.B-The side effects may be avoided by following low fat, reduced-calorie diet.
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Precaution for consuming Xenical Drug
The patients taking Xenical should consume multi vitamin tablet containing vitamin A, D, E, K and beta- carotene once a day before bedtime as Xenical inhibits absorption of fat-soluble vitamins and fat- soluble nutrients.
Success of Xenical 120 mg
It is not only the medicine that can overcome the threat of ‘obesity’, ‘the leading preventable cause of death’. Dieting, physical exercise and a conscious art of living as well are necessary to eliminate the curse of obesity from our life. |
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